Apr 02 Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins
Suhas Srinivasan, Hongzhu Cui, Ziyang Gao, Ming Liu, Senbao Lu, Winnie Mkandawire, Oleksandr Narykov, Mo Sun and Dmitry Korkin
ABSTRACT
During its first two and a half months, the 2019 novel coronavirus, SARS-CoV-2, has already infected more than one hundred thousand people worldwide.
However, the rapidly spreading virus also caused an unprecedented rapid response from the research community facing an unknown health challenge with enormous potential. Unfortunately, experimental research to understand the molecular mechanisms behind viral infection and design a vaccine or antiviral is expensive and takes months to develop.
To accelerate the advancement of our knowledge, we take advantage of data on related coronaviruses, which is readily available in public databases, and integrate this computerized data into a single database.
As a result, we provide the comprehensive maps of the structural genomics and interactomics of SARS-CoV-2. This information can be used to infer possible functional differences and similarities with the SARS coronavirus. All data is made publicly available to the research community.