Apr 02 Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic
Eakachai Prompetchara, Chutitorn Ketloy, Tanapat Palaga
ABSTRACT
As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidence suggest a path similar to that of SARS and MERS. Rapid genomic sequencing and available access data, together with advanced vaccine technology, are expected to give us more knowledge about the pathogen itself, including the host immune response, as well as the plan for therapeutic vaccines in the future. nearby.
This review aims to provide a comparative view between SARS-CoV, MERS-CoV and the new SARS-CoV-2 epidemic, hoping to gain a better understanding of host-pathogen interaction, host immune responses and pathogen immune evasion strategies. This predictive insight may help design an immune intervention or preventive vaccine for COVID-19 in the near future.