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Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Hussin A. Rothana, Siddappa N. Byrareddy

Apr 07 Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Posted at 18: 45h in COVID-19 by

Andrew M. South, Laurie Tomlinson, Daniel Edmonston, Swapnil Hiremath and Matthew A. Sparks

Nat Rev Nephrol (2020). https://doi.org/10.1038/s41581-020-0279-4

ABSTRACT

The current COVID-19 pandemic is associated with unprecedented morbidity and mortality.

Early reports suggested an association between disease severity and hypertension. The virus responsible for SARS-CoV-2 is facilitated in its entry to host cells through the angiotensin-converting enzyme 2 (ACE 2), highlighting the need to understand the relationship between the virus and the renin-angiotensin system (RAS) and how this may be affected by RAS inhibitors.

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