Clinical characteristics of 140 patients infected with SARSCoV-2 in Wuhan, China

View pdf

ABSTRACT

Background: Infection with coronavirus syndrome 2 (SARS-CoV-2) has spread widely. The objective was to investigate the clinical characteristics and allergy status of patients infected with SARS-CoV-2.

Methods: Electronic medical records, including demographic data, clinical manifestations, comorbidities, laboratory data and radiological materials of 140 patients hospitalized for COVID-19, with confirmed results of SARS-CoV-2 viral infection.

Results: 

• An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found with an overall mean age of 57.0 years.
• All patients were infected via the community.
• Most frequent clinical manifestations:
  • Fever (91.7%)
  • cough (75.0%)
  • fatigue (75.0%)
  • Gastrointestinal symptoms (39,6%)
• Most frequent comorbidities:
  • Hypertension (30.0%)
  • Diabetes mellitus (12.1%)
• Reported by several patients:
  • Hypersensitivity to medications (11.4%)
  • Hives (1.4%)
• Asthma or other allergic diseases were not reported by any of the patients.
• Patients with chronic obstructive pulmonary disease (COPD, 1,4%) and current smokers (1.4%) were rare.
• Radiological signs:
  • Bilateral ground glass or irregular opacity (89,6%) was the most common. sign of radiological finding.
  • Lymphopenia (75,4%) and eosinopenia (52,9%) were observed in the majority of patients. Blood eosinophil counts were positively correlated with lymphocytes in severe (r = .486, P <.001) and non-severe (r = .469, P <.001) patients after hospital admission.
• Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared with non-severe patients (all P <.001).

Conclusion: Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests that eosinopenia along with lymphopenia may be potential indicators for diagnosis.
Allergic diseases, asthma and COPD are not risk factors for SARS-CoV-2 infection.
Advanced age, a high number of comorbidities, and laboratory abnormalities were associated with severe patients.